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Takeda Pharmaceuticals Principal Scientist/ Staff, Process Chemist for oligonucleotide drug substance in Fujisawa, Japan

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Job Description

Please note this job requires native level Japanese language command not only in speaking, business writing and reading.


Takeda is unwavering in our commitment to patients. With the patient at the center of everything we do, we continue to innovate and drive changes that will better their lives - we’re looking for like-minded professionals to join us.

Takeda is a global industry leader –we are united by our four priorities (Patients, Trust, Reputation, and Business) and our shared values of Takeda-ism ( : Integrity, Fairness, Honesty, and Perseverance. Takeda-ism is more than just a word. It’s a belief and a mindset which guides our decisions, behaviors, and interactions. It’s how we strive to work and live, every day.




Role and responsibility of Process Chemistry Development (PCD) is process research and development of synthetic Drug Substance (DS) including small molecules, peptides and oligonucleotides from pre-clinical to NDA and tech-transfer to commercial manufacturing division. Also, PCD manufactures and supplies DS to non-clinical studies and clinical studies with suitable quality.

プロセスケミストリーデベロップメント (PCD)は、低分子・ペプチド・オリゴ核酸などの合成原薬のプロセス研究開発を前臨床段階から商用申請まで行い、商用製造部門へ技術移管します。また、PCDは非臨床および臨床試験のために適切な品質の原薬を製造・供給します。


  • Process research and development of oligonucleotide DS.

  • In process analysis of oligonucleotide, including impurity analysis using LCMS.

  • Tech-transfer to the contract development and manufacturing organizations (CDMOs) of oligonucleotide DS and manage them for the DS manufacturing.

  • IND/NDA documentation.

  • Collaborative work with global stakeholders/teams.

  • Establishment of development strategy with teams.

  • オリゴ核酸原薬のプロセス研究開発。

  • オリゴ核酸原薬のIn process analysis (LCMSを用いた類縁物質解析含む)。

  • DS CDMOへの技術移管、およびCDMOでのオリゴ核酸原薬製造の管理。

  • IND/NDA文書の作成。

  • グルーバル関係者/チームとの協働。

  • チームでの開発戦略の作成。



  • Ph.D. or M.S. and 2+ years of industry experience of oligonucleotide DS synthesis.

It is preferable to have the following experience/skills.

  • Process R&D and scale-up of oligonucleotide DS by solid phase synthesis.

  • Synthesis of special ligands or amidites.

  • The skill set of impurity analysis of oligonucleotide using MS software.

  • Understanding the basic GMP manufacturing requirements.

  • Good written and verbal communication skills in Japanese and English (for example, TOEIC score: 730 or higher).

  • IND submission of oligonucleotide DS.

  • 博士または修士卒で、オリゴ核酸原薬合成に2年以上の業務経験。


  • オリゴ核酸原薬の固相合成でのプロセス検討とスケールアップ。

  • 特殊アミダイト、特殊リガンドの合成。

  • MSソフトを使用したオリゴ核酸の類縁物質解析技術。

  • 基礎的なGMP製造の理解。

  • 文書作成および口頭でのコミュニケーションが、日本語と英語の両方で可能(例えばTOEIC score 730点以上) 。

  • オリゴ核酸原薬のIND申請。


  • Collaborative mindset with good transparency to global stakeholders.

  • Highly motivated to cure patients using oligonucleotides.

  • Ambitious to broaden own responsibility and opportunities, from early stage to commercial.

  • グローバル関係者に対して透明性の高い協調的なマインドセットを有していること。

  • オリゴ核酸を用いて患者様を治療したいという高いモチベーションを有していること。

  • 初期段階から商用段階に至るまで、自らの責任と機会を広げることに意欲的であること。


Allowances: Commutation, Housing, Overtime Work etc.

Salary Increase: Annually

Bonus Payment: Twice a year

Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, Research Site (Kanagawa) 9:00-17:45

Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)

Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave.

Flexible Work Styles: Flextime, Telework

Click here ( to find out Takeda’s Diversity, Equity & Inclusion

Better Health, Brighter Future



賞与: 原則年2回

勤務時間:本社(大阪市中央区・東京都中央区)9:00~17:30 、工場(山口県光市・大阪市淀川区)8:00~16:45 、研究所(神奈川県藤沢市)9:00~17:45




タケダのDE&I (

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Fujisawa, Japan

Worker Type


Worker Sub-Type


Time Type

Full time