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Job ID360112 LocationTwin Cities Job FamilyResearch-Researchers Full/Part TimeFull-Time Regular/TemporaryRegular Job Code9742R6 Employee ClassAcad Prof and Admin About the Job Position Summary This is a research position within a laboratory at the interface of virology, microbial ecology and mucosal immunology studying mechanisms by which respiratory viruses like influenza and respiratory syncytial virus cause disease in humans. The position offers the opportunity to interact with physician-scientists and develop skills in a variety of research techniques, experimental approaches and research questions relevant to human health, including primary human cell culture, molecular virology and analysis of multiomics data. The Researcher 6 is expected to design and independently manage one or more research projects. After consultation with the PI on scope, the successful candidate will be expected to identify appropriate methodology, execute experiments, and report results independently. The successful candidate will act as a secondary mentor and supervisor for trainees in the laboratory, assisting them with project design and experiments when appropriate. The researcher will be expected to be able to independently draft manuscript and grant applications and will have opportunities to submit applications for funding as a co-PI or Co-I. Assist with the day-to-day management of the lab, including ordering, compliance, and budget management. Represent the research group scientifically at an international level. Network with other scientific colleagues and help build and maintain collaborations that will drive the research program forward. Our lab seeks to foster an inclusive environment in which members from diverse backgrounds are encouraged to develop their skills of scientific inquiry. A successful candidate will be a curious, self-motivated team player. This position supports flexible work hours upon prior arrangement with PI. The candidate in this position will be designated as an Essential Employee. Essential Employees are expected to report to campus during a University State of Emergency (reduced operations or campus closure) unless specifically directed by the Department not to report or if directed by civil emergency or medical authorities not to report for health and safety reasons. As an Essential Employee, the candidate must report to campus even if the closure if less than 3 days. Duties/Responsibilities 60% Experiment design and execution. Development and execute molecular assays for detection of human microbial pathogens (nucleic acid extraction, reverse transcription, PCR, qPCR) Next-generation sequencing (development of hybrid capture assays for respiratory pathogen genome sequencing, 16S rRNA sequencing, 28S/ITS rRNA sequencing) In vitro experimentation in human respiratory tract model systems (propagation of bacterial and/or fungal stocks, air-liquid interface microbial-viral-human cell co-culture systems, organoid culture) Perform in vitro virological assays (preparation and titering of viral stocks, viral infection assays) Perform assay of human immune function (multi-parameter flow cytometry, ELISA) Expand repertoire of fungal studies within the lab 20% Data analysis and manuscript preparation. Independent data analysis and figure preparation Collaborate with PI on manuscript and grant writing. Assist junior scientists with experimental design and troubleshooting and writing projects 20% Lab management and administration. Assist with lab organization Assist with maintenance of lab equipment Supervise junior lab members in specimen kit shipping. receiving and logging in laboratory database for clinical studies (MINNE-LOVE and MINNE-LOVE-2) Supervise junior members of the lab in reagent preparation Co-mentor trainees (undergraduates, graduate students, and fellows) with the PI Supervise inventory and ordering Assist with research compliance (IBC, IRB) Assist with laboratory financial management Qualifications Requi ed Qualifications - Advanced degree (e.g. PhD, MD, DVM) and a substantial research and publication record. - At least 5 years of research experience, including experience in independent project management and supervision and mentorship of junior scientists - Facility with standard molecular biology techniques, including nucleic acid extraction, reverse transcription, and PCR/qPCR - Strong organizational skills - Excellent written, verbal and interpersonal skills - Ability to work independently and as a part of a diverse team Preferred Qualifications Experience with lab management - Experience with next-generation sequencing techniques (Oxford Nanopore preferred) - Experience with standard microbial culture techniques (bacterial, fungal) - Familiarity with concepts of microbial phylogeny and associated analysis tools - Familiarity with R and/or Python, ability to perform basic bioinformatic analyses independently and work with more experienced bioinformaticians for more complex analyses - Experience with risk-mitigation strategies for handling potentially infectious human pathogens in a BSL-2 enviroment - Experience with standard mammalian tissue culture techniques - Prior training and experience conducting research involving human subjects or willingness to complete such training (CITI, HIPAA) About the Department University of Minnesota Medical School Committed to innovation and diversity, the Medical School educated physicians, scientists, and health professionals; generates knowledge and treatments; and cares for patients and communities with compassion and respect. We value excellence, inclusiveness, collaboration, and discovery. The mission of the regional campus located in Duluth is to be a national leader in improving healthcare access and outcomes in rural Minnesota and American Indian/Alaska Native (AI/AN) communities. In partnership with CentraCare, the regional campus in St. Cloud offers a wide range of patient experiences throughout students' education in Greater Minnesota and prepares them to become exceptional clinicians and leaders for rural and immigrant populations. Benefits Working at the University At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work. The University also offers a comprehensive benefits package that includes: Competitive wages, paid holidays, and generous time off Continuous learning opportunities through professional training and degree-seeking programs supported by the Low-cost medical, dental, and pharmacy plans Healthcare and dependent care flexible spending accounts University HSA contributions Disability and employer-paid life insurance Employee wellbeing program Excellent retirement plans with employer contribution Public Service Loan Forgiveness (PSLF) Financial counseling services Employee Assistance Program with eight sessions of counseling at no cost Please visit the for more information regarding benefits. How To... For full info follow application link. The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds. The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu.