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The Jurynec Lab (Department of Orthopaedics, www.juryneclab.org) is looking for a highly motivated and independent Post Doctoral Research Fellow to be part of a multidisciplinary team studying the genetics of osteoarthritis. The lab uses human genetics, bioinformatics, molecular biology, and animal models to understand the factors that contribute to the onset and progression of osteoarthritis.The Jurynec Lab has identified over 100 candidate gene variants that segregate with osteoarthritis in large pedigrees. We are analyzing candidate gene functions in zebrafish and generating mice carrying human disease alleles to understand the contribution of these genes to the osteoarthritis phenotype. Analyses include CRISPR/Cas9 genome editing in mice and zebrafish, scRNA-seq, spatial profiling, WES/WGS, and tissue culture. The candidate should be prepared to analyze gene function in vivo and perform genetic and chemical screens in vitro to identify potential therapeutics.The lab is funded by the NIH and foundation grants. The applicant will be responsible for leading independent projects under the guidance of the PI. These studies include performing experiments with zebrafish, mice, and tissue culture. The applicant will also be responsible for the maintenance and breeding of zebrafish and mice.