Job Information
Sartorius Principal Scientist - iPSC Engineering & Manufacturing Processes - On-site Marlborough, MA in United States
Sartorius’ Emerging Therapies Services team in the Greater Boston (MA) area is a part of Corporate Research Group and is engaged in the design, development, and optimization of iPSC engineering and manufacturing processes that can be transformed from early pre-clinical stage into cGMP ready manufacturing scale. As the Principal Scientist, you will be expected to work closely together with an internal multi-disciplinary product development team, to create forward looking processes that provide a basis for commercial manufacturing that can be integrated into our process solution offering.
Sartorius is seeking an individual with drive, and passion, to be part of a newly developed team based in our Marlborough, MA office. As part of the Corporate Research team, you will lead design and optimize protocols for the differentiation of iPSCs into specific cell types using cutting-edge techniques.
If you are interested in joining a company known for a great culture, innovative technologies and potential for career growth opportunities then please read on.
To drive the creation of new innovative biomanufacturing solutions, Sartorius has formed an initiative to discover new trends and cutting-edge opportunities for rapid conversion towards next generation continuous and integrated closed manufacturing solutions. This exciting initiative enables the research, process development and clinical production of novel modalities using next generation manufacturing platforms, in partnership with key customers.
What you will accomplish together with us:
You will design and optimize protocols for the differentiation of iPSCs into specific cell types using cutting-edge techniques aimed at enhancing the efficiency and scalability of the differentiation processes.
One of your tasks will be to lead cross-functional teams, to scale iPSC expansion and differentiation from benchtop to production scale bioreactors.
You will develop and write process development proposals, conduct hands-on laboratory work to optimize and troubleshoot upstream and downstream manufacturing processes for iPSCs and iPSC derived cells and tissues.
In this role, you will analyze and interpret data ensuring clear documentation of methodologies and outcomes.
You will prepare detailed reports and presentations for internal and external partners to communicate progress in line with project schedules.
You will assist in mentoring and training junior team members and coordinating the day-to-day operations.
Your duties will include leading and managing multiple high impact internal and external research projects by establishing priorities, milestones, schedules, and deadlines.
You will be responsible for writing, reviewing, and maintaining electronic lab notebooks with the highest level of research integrity.
You will be responsible for writing project reports, briefs, protocols and making presentations to internal and external partners and project teams as required.
In this role, you will lead technology transfer activities to internal and external collaborators.
You will support marketing efforts by writing technical briefs, application notes and peer reviewed publications, leading or assisting with technical presentations at scientific conferences.
Your tasks include conducting technical investigations and risk assessments related to processes.
Support marketing efforts by writing technical briefs, application notes and peer reviewed publications, leading or assisting with technical presentations at scientific conferences.
Support generation of protocols, work instructions, batch records and reports.
Work independently in a matrixed environment.
Perform occasional extended hours and weekends to support ongoing lab activities as needed.
On an as needed basis, you will mentor and support junior staff and build a culture of support and collaboration.
Comply with all site policies such as record retention, ISO requirements, and accountable for good housekeeping in all laboratories.
Comply with biohazard, special clean room and site safety/health procedures and guidelines as required.
Assist other team members and site management team with miscellaneous duties when requested.
What will convince us:
Education:
- You possess a Ph.D. (with 6+ years of industry experience) in chemical, biochemical or biomedical engineering, engineered cell therapies or related field.
Experience:
Extensive expertise in generating, differentiating, expanding and characterizing pluripotent cells and their derivatives.
Expertise in differentiating pluripotent cells into multiple clinically relevant lineages in planar and bioreactor systems.
Hands-on experience with multiplexed genome editing technologies and single cell cloning is a plus.
Knowledge of GxPs, experience in process development or GMP operation is a plus.
Demonstrated ability to design, plan, and implement pluripotent cell differentiation protocols.
Experience in the design and execution of current molecular biology and biochemical assay techniques including PCR, qPCR, ddPCR, NGS, WB, IF, ELISA, and Flow Cytometry is highly desirable.
Direct experience in genome editing mammalian cells is highly preferred. Experience & knowledge of state-of the-art upstream and downstream technologies for cell growth, transfection, propagation, and purification for application for process development workflow.
Experience working as part of multi-partner R&D projects.
Experience with documentation control systems.
Familiarity with relevant guidelines from the FDA, EMA and ICH
We value:
Strong analytical and mathematical ability.
Ability to work independently and constructively in a team environment.
Must have strong personal initiative and be results oriented.
Strong troubleshooting skills.
Strong written and verbal communication skills, capable of clearly expressing technical concepts to people with various levels of technical expertise and diverse cultural backgrounds.
Identification with our core values: Sustainability, Openness, Enjoyment
Working Conditions/Environment (ex. Any irregular or unusual work schedules, travel, etc):
Travel 10-20% of time, both foreign and domestic. Work on weekends as required. Work in a Biosafety Level 2 Laboratory.
What We Offer
As a growing global life science company, with our stock listed on the German DAX and TecDAX , Sartorius offers a wide range of benefits: Personal and Professional Development: Mentoring, leadership programs, LinkedIn Learning, internal seminar offerings Worklife Balance: Paid vacation, sick time, corporate holidays and community service day; as well as flexible work schedules Making an Impact Right from the Start: Comprehensive onboarding, including a virtual online platform Welcoming Culture: Mutual support, team spirit and international collaboration; communities on numerous topics such as “Coaching”, “Agile Working” and a “Businesswomen’s Network” Health & Well Being: Wide selection of health and well-being support such as a variety of medical plans to choose from, dental, vision, EAP, and other wellness programs. Intelligent Working Environment: Working in smart buildings with the latest technology and equipment.
Retirement Savings Plan: 401 k (with generous company match) Flexible Spending: HSA, FSA (dependent care & healthcare spending), Transportation Commuter Account Company Paid Benefits: Basic Life Insurance, AD&D, EAP, Family Planning & Women’s Health, Health Advocate Additional/Optional: Supplemental Life Insurance (employee, spouse & dependents), Legal Services, LTD & STD, Critical Illness Insurance, Student Loan Tuition Refinance Service
All qualified applicants will be considered for employment without regard to race, color, religion, sex or national origin. We are also an equal opportunity employer of individuals with disabilities and protected veterans.
Please view equal employment opportunity posters provided by OFCCP here (https://www.dol.gov/agencies/ofccp/posters) .
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Sartorius is part of the solution in the fight against cancer, dementia, and many other diseases. Our technologies help translate scientific discoveries into real-world medicine faster, so that new therapeutics can reach patients worldwide. We look for ambitious team players and creative minds, who want to contribute to this goal and advance their careers in a dynamic global environment. Join our global team and become part of the solution. We are looking forward to receiving your application.
We look forward to receiving your application.
www.sartorius.com/career
Sartorius is an Equal Opportunity/Affirmative Action employer and will consider all qualified applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status.
All employment decisions are based on valid job-related requirements.
If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening. You can request reasonable accommodation by calling +1 631 254 4249 ext 8330 or via e-mail at accommodationrequest@sartorius.com
About Sartorius
Sartorius is part of the solution in the fight against cancer, dementia, and many other diseases. Our technologies help translate scientific discoveries into real-world medicine faster, so that new therapeutics can reach patients worldwide.
We look for ambitious team players and creative minds, who want to contribute to this goal and advance their careers in a dynamic global environment.
Join our global team and become part of the solution. We are looking forward to receiving your application. www.sartorius.com/careers