Merck Principal Scientist in West Point, Pennsylvania
Our Scientists are our Inventors. We deliver robust scientific data and interpretation that drives the commercialization of breakthrough therapeutics using innovative thinking, state-of-the-art facilities, and modern equipment. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity, and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement, and teamwork. As part of our global team, you will have the opportunity to collaborate with talented and dedicated colleagues while developing your career.
The Analytical Research and Development, Cell Based Sciences Department in West Point, PA is seeking a motivated Principal Scientist with technical expertise in developing reagents for large molecule potency assays. Specifically, the ideal candidate will be a recognized expert in developing antibodies that enable mechanism-of-action reflective potency assays. This is a laboratory-based scientific role tasked with solving complex analytical problems at the interface of biology, chemistry, and lab informatics disciplines to enable development of Vaccine candidates.
The successful candidate is expected to provide scientific leadership, expertise, and creativity to solve complex project problems across the large molecule portfolio. They will be accountable to inspire and sponsor scientific evaluation and implementation of innovative and disruptive technologies and approaches. Responsibilities include representing the group on product development teams, developing strategy for reagent development and characterization, oversight of method development and testing, and scientific mentoring. The candidate will be expected to effectively communicate with stakeholders in partner organization and to management and governance teams.
Ph.D. in analytical chemistry, molecular biology, cell biology, virology, or related field with a minimum of 8 years of relevant experience;
OR M.S. with a minimum of 10 years of experience;
OR bachelor's with a minimum of 14 years of experience in the Pharmaceutical Industry.
Required Skills and Experience:
In-depth knowledge and understanding of immunoassay development including antigen and antibody selection, antibody matched pair screening and optimization, binding kinetics, and multiplexing.
Deep technical knowledge of antibody generation, characterization, and application within large molecule analytical and process development.
Expertise in cell biology and immunology, with application to solve complex scientific challenges related to designing and developing GxP potency assays to support a variety of vaccine modalities.
Demonstrated ability to lead complex experimental design and detailed data analysis concepts related to analytical method development.
Deep working knowledge of regulatory guidance and quality standards, with experience authoring and reviewing regulatory submissions and responses (biologics license application submission) and interacting with Health Authorities.
Ability to excel in a team-based environment, partnering and influencing in a professional and positive manner.
Strong external scientific reputation including publications, regulatory guidance documents, presentations at scientific meetings, membership on (or leading) cross-company working groups or consortia.
Excellent verbal and written communications skills.
Demonstrated scientific ability through publications and presentations in scientific conferences.
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Requisition ID: R258871
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